Role of anion gap and different electrolytes in hypertension during pregnancy (preeclampsia) |
| |
Authors: | Manoj Kumar Kashyap Shilpi V Saxena Madhu Khullar Harjit Sawhney Kala Vasishta |
| |
Institution: | (1) Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India;(2) Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India;(3) Morphology Division, Department of Veterinary Biosciences, College of Veterinary Medicine, University of IL, VB 3644, Urbana-Champaign, IL 61802, USA |
| |
Abstract: | The present study was designed to determine the changes in serum sodium, anion gap, different antioxidants and free radicals
in preeclamptic patients and control subjects. Serum sodium, chloride, bicarbonate, calcium, potassium and magnesium were
estimated and anion gap was determined in 100 proteinuric hypertensive and 100 normotensive pregnant women. Mean serum sodium,
chloride and bicarbonate level (133.26 ± 13.1, 104.97 ± 11.37, and 22.01 ± 4.66 mEq/l, respectively) were significantly higher
in proteinuric hypertensive women as compared to controls (125.85 ± 10.4, 101.90 ± 6.3, 19.34 ± 3.21 mEq/l, respectively)
whereas anion gap level (6.28 ± 16.147) was nonsignificantly higher in proteinuric hypertensive as compared to normotensive
(4.61 ± 11.84). Total serum sodium concentration increases in preeclamptic subjects, the exact distribution of serum sodium
in various compartments of the body are not clear and correlation of serum sodium and anion gap with proteinuria is also not
known. The levels of different antioxidants were decreased in preeclamptic patients as compared to the controls while the
level of free radicals elevated in preeclamptic subjects as compared to controls. In our study, anion gap level was found
to be rather non-significantly higher in proteinuric hypertensive women as compared to normotensive women. |
| |
Keywords: | anion gap electrolytes glutathione hypertension lipid peroxidation preeclampsia pregnancy |
本文献已被 PubMed SpringerLink 等数据库收录! |
|