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Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines |
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| Authors: | Gillespie Roger J Cliffe Ian A Dawson Claire E Dourish Colin T Gaur Suneel Jordan Allan M Knight Antony R Lerpiniere Joanne Misra Anil Pratt Robert M Roffey Jonathan Stratton Gemma C Upton Rebecca Weiss Scott M Williamson Douglas S |
| Institution: | aVernalis (R&D) Ltd, 613 Reading Road, Winnersh RG41 5UA, UK bVernalis (R&D) Ltd, Granta Park, Cambridge CB21 6GB, UK |
| Abstract: | A series of pyrazolo3,4-d]pyrimidine, pyrrolo2,3-d]pyrimidine and 6-arylpurine adenosine A2A antagonists is described. Many examples were highly selective against the human A1 receptor sub-type and were active in an in vivo model of Parkinson’s disease. |
| Keywords: | Adenosine A2A receptor antagonists Parkinson’s disease Pyrazolo[3 4-d]pyrimidine Pyrrolo[2 3-d]pyrimidine Purine |
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