Interferon production by mammalian cells grown in a serum-free medium |
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| Authors: | Robert W. Pumper Leonard Molander |
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| Affiliation: | (1) Department of Microbiology and Immunology, University of Illinois College of Medicine, P. O. Box 6998, 60680 Chicago, Illinois;(2) St. James Hospital, Chicago Heights, Illinois |
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| Abstract: | Summary Interferon, produced by rabbit heart cells grown in a serum-free medium, failed to protect rabbit heart serum-free cells, but protected rabbit heart serum-containing-medium cells against vaccinia and vesicular stomatitis virus. Interferon produced in serum-free cells had a greater species specificity than that produced in serum-containing media. The difference in activity was shown to be due to lack of adsorption by serum-free-medium cells. |
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| Keywords: | interferon cell cultures peptone media vaccinia vesicular stomatitis virus |
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