The stem cells of a primordial germ cell-derived teratocarcinoma have the ability to form viable mouse chimeras |
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| Authors: | Kazunori Hanaoka Michiko Hayasaka Takehiko Noguchi Yoshihiro Kato |
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| Institution: | Laboratory of Mammalian Developmental Biology, Mitsubishi-Kasei Institute of Life Sciences, Tokyo, Japan. |
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| Abstract: | A euploid testicular teratocarcinoma line, STT-3, has been established from a tumor spontaneously occurring in the testis of a 129/Sv-ter male. Developmental ability of the STT-3 stem cells was tested by injecting these cells into mouse blastocysts. The frequency and the extent of chimerism were examined in mid-gestational fetuses and in live-born mice. STT-3 stem cells form viable chimeras at a high rate and differentiate into normal tissues. This is the first reported testicular teratocarcinoma-derived stem line with a proven capacity to form viable chimeric mice upon injection into the blastocysts. |
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