Trace-level sensing of dopamine in real samples using molecularly imprinted polymer-sensor |
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| Affiliation: | 1. Department of Chemistry and Chemical Processing Technologies, Erzurum Vocational College, Atatürk University, Erzurum 25240, Turkey;2. Department of Nanoscience and Nanoengineering, Nanomaterials Sciences, Atatürk University, Erzurum 25240, Turkey;1. Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu 808-0196, Japan;2. Department of Biotechnology, Faculty of Science, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh 484886, India;3. Department of Chemistry, Faculty of Science, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh 484886, India;4. Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India;1. School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China;2. Institute of Functional Materials and Agricultural Applied Chemistry, Jiangxi Agricultural University, Nanchang 330045, PR China |
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| Abstract: | Induced-fit responsive dopamine (DA) imprinted polymer, poly (melamine-co-chloranil), was used as a suitable coating material for the modification of a hanging mercury drop electrode. The zwitterionic conformation of the imprinted polymer responded differential pulse, cathodic stripping voltammetric current, without any false-positive or false-negative contributions of non-specific sorptions, in aqueous environment of complex matrices. The limit of detection (3σ) of dopamine was found to be as low as 0.148 ng mL−1, by the proposed sensor that could be considered a sensitive marker of dopamine depletion in Parkinson's disease (PD). |
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