High production of hyaluronic and lactic acids by Streptococcus zooepidemicus in fed-batch culture using commercial and marine peptones from fishing by-products |
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| Institution: | 1. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan;2. Department of Cell and Molecular Biology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan;3. Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan;4. Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan;5. Department of Orthopaedic Surgery, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan;6. Department of Life Science, National Taiwan Normal University, Taipei, Taiwan |
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| Abstract: | The combined production of biomass, hyaluronic acid (HA) and lactic acid (LA) in a glucose fed-batch system was studied. The complex culture media used were formulated with commercial and residual peptones from fish by-products. In all cases, fed-batch fermentations increased the productive period of HA and LA. Tryptone led to the highest productions but with the peptones from shark by-products similar LA concentrations and prominent HA levels were reached. Moreover, with this residual peptone higher molecular weight of HA were achieved. On the other hand, the equations proposed adjusted with accuracy and high statistical robustness the experimental kinetic profiles. |
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