Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer,antibacterial, antifungal,and other clinical applications |
| |
Institution: | 1. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan;2. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10463, USA;3. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran;4. Department of Pharmacy, University of Swabi, Pakistan;5. Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan |
| |
Abstract: | Many cyclic peptides and analogues derived from marine sources are known to possess biological properties, including anticancer, antitumor, antibacterial, antifungal, antiparasitic, anti-inflammation, anti-proliferative, anti-hypertensive, cytotoxic, and antibiotic properties. These compounds demonstrate different activities and modes of action according to their structure such as cyclic oligopeptide, cyclic lipopeptide, cyclic glycopeptide and cyclic depsipeptide. The recent advances in application of the above-mentioned cyclic peptides were reported in dolastatins, soblidotin, didemnin B, aplidine, salinosporamide A, kahalalide F and bryostatin 1 and they are currently in clinical trials. These cyclic peptides are possible novel drugs discovered and developed from marine origin. Literature data concerning the potential properties of marine cyclic peptides were reviewed here, and the structural diversity and biological activities of marine cyclic peptides are discussed in relation to the molecular mechanisms of these marine cyclic peptides. |
| |
Keywords: | Cyclic peptides Marine organism Anticancer Antibacterial Antifungal |
本文献已被 ScienceDirect 等数据库收录! |
|