| 黄芪、人参增强人心肌细胞抗病毒感染的实验研究——降低对病毒敏感性及诱生干扰素作用 |
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| 引用本文： | 魏然,陈晨华,董杰德,仇素英,曹宗离.黄芪、人参增强人心肌细胞抗病毒感染的实验研究——降低对病毒敏感性及诱生干扰素作用[J].Virologica Sinica,1992(1). |
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| 作者姓名： | 魏然 陈晨华 董杰德 仇素英 曹宗离 |
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| 作者单位： | 山东医科大学微生物学教研室，山东医科大学微生物学教研室，山东医科大学微生物学教研室，山东医科大学微生物学教研室，山东医科大学微生物学教研室 济南 250012，济南 250012，济南 250012，济南 250012，济南 250012 |
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| 基金项目： | 本文为国家自然科学基金资助课题 |
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| 摘 要： | 在培养的人心肌细胞上研究了黄芪、人参抗Cox B-3及Echo-19病毒的作用及诱生干扰素的效应,结果表明两种药物分别作用于人心肌细胞48小时及感染病毒的心肌细胞在含药物的营养液中培养均可降低细胞对两种病毒感染的敏感性,此作用与药物诱导心肌细胞产生IFN有关。
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| 关 键 词： | 黄芪 人参 人心肌细胞 柯萨奇B-3病毒 Echo 19病毒 |
Studies on the Effect of AM and RG in Enhancing the Antiviral Activity of Human Myocardial Cells in Vitro |
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| Wei Ran,Chen Chen-hun,Dong Jie-de,Qiu Su-ying,Cao Zong-li.Studies on the Effect of AM and RG in Enhancing the Antiviral Activity of Human Myocardial Cells in Vitro[J].中国病毒学(英文版),1992(1). |
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| Authors: | Wei Ran Chen Chen-hun Dong Jie-de Qiu Su-ying Cao Zong-li |
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| Institution: | Wei Ran,Chen Chen-hun,Dong Jie-de,Qiu Su-ying,Cao Zong-li Department of Microbiology,Shandong Medical University,Jinan 250012 |
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| Abstract: | In this study, we assayed the antiviral effect of AM and RG againstCoxsackie B-3 and Echo-19 viruses and the influence of these two drugs onthe susceptibility of human heart cells to viral infection. Results of the studyrevealed the following: human heart cells, depleted endothelial cells and fibro-blasts by 2 hours adsorption, grown up to monolayer by 9th-10th day, survi-ved more than one month. AM and RG have no direct inactivating effect onCox B-3 and Echo-19 viruses. Heart cells pretreated with AM and RG for48 hours before infection and treated with the drugs after viral infection re-sulted in lowered susceptibility of heart cells to viral infection. The antiviralactivity of the cells induced by AM or RG may be related to its effect to in-(duce and enhance IFN production. |
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| Keywords: | Astragalus membranaceus Radix ginseng Human myocardiall cell Cox B-3 virus Echo 19 virus |
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