Synthesis, crystal structure, magnetic property and nuclease activity of a new binuclear cobalt(II) complex |
| |
Authors: | Tian Jin-Lei Feng Li Gu Wen Xu Guang-Jun Yan Shi-Ping Liao Dai-Zheng Jiang Zong-Hui Cheng Peng |
| |
Institution: | Department of Chemistry, Nankai University, Tianjin 300071, PR China. |
| |
Abstract: | One new binuclear Co(II) complex of N,N,N',N'-tetrakis(2-benzimidazolylmethyl)-2-hydroxyl-1,3-diaminopropane (HL), Co(2)L(mu(2)-Cl)](ClO(4))(2) x 3CH(3)CN x C(2)H(5)OC(2)H(5) (1), has been synthesized and its crystal structure and magnetic properties are shown. In 1, each Co(II) atom has a distorted trigonal bipyramidal geometry with a N(3)OCl donor set. The central two Co(II) atoms are bridged by one alkoxo-O atom and one Cl atom with the Co1-Co2 separation of 3.239 A. Susceptibility data of 1 indicate strong intramolecular antiferromagnetic coupling of the high-spin Co(II) atoms. In this paper, the interaction with calf thymus DNA was investigated by UV absorption and fluorescent spectroscopy. Results show the complex binds to ct-DNA with a intercalative mode. The interaction between complex 1 and pBR322 DNA has also been investigated by submarine gel electrophoresis, noticeably, the complex exhibits effective DNA cleavage activity in the absence of any external agents. |
| |
Keywords: | Binuclear Co(II) complex DNA cleavage Crystal structure Magnetic property |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|