5(Z)-benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators |
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| Authors: | Ardecky Robert J Hudson Andrew R Phillips Dean P Tyhonas John S Deckhut Charlotte Lau Thomas L Li Yongkai Martinborough Esther A Roach Steven L Higuchi Robert I Lopez Francisco J Marschke Keith B Miner Jeffrey N Karanewsky Donald S Negro-Vilar Andrés Zhi Lin |
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| Affiliation: | Discovery Research, Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, CA 92121, USA. |
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| Abstract: | ![]()
A series of 5-benzylidene-1,2-dihydro-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes was synthesized and profiled for their ability to act as selective glucocorticoid receptor modulators (SGRMs). The synthesis and structure-activity relationships for this series of compounds are presented. |
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