In Vivo Elevation of Mouse Brain S-Adenosyl-L-Homocysteine after Treatment with L-Homocysteine |
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Authors: | A. Gharib,B. Chabannes,N. Sarda,H. Paché co |
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Affiliation: | Laboratoire de Chimie Biologique, Institut National des Sciences Appliquées, Villeurbanne, France |
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Abstract: | Intraperitoneal coadministration of adenosine and L-homocysteine markedly increased S-adenosyl-L-homocysteine in whole mouse brain, but further investigations showed that this elevation could also be produced following administration of L-homocysteine alone. The noted increase was maximal (+1325%) 10 min after treatment, remaining at about this level for 30-40 min before returning to control values after 180 min. Cerebral adenosine levels were decreased after treatment with L-homocysteine, adenosine, or these two substances in combination. |
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Keywords: | l-Homocysteine Adenosine S-Adenosyl-l-homocysteine S-Adenosyl-l-methionine Mouse brain. |
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