Translocation t(1;17)(q12;q25) with a clinical picture like of a proximal deletion of 1q: identification by in situ hybridization with chromosome 1-specific satellite DNA probes |
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| Authors: | Swetlana G. Vorsanova Y. B. Yurov M. B. Kurbatov L. Z. Kazantzeva |
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| Affiliation: | (1) Institute of Pediatrics and Children's Surgery, MH of the USSR, Taldomskaya str. 2, 127 412 Moscow, USSR |
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| Abstract: | Summary The authors report a case of a balanced 1;17 translocation with breakpoints located in the secondary constriction of chromosome 1. This translocation is associated with pathological symptoms similar to those observed following a proximal deletion of 1q. We request contact with colleques who have observed similar, or related, cases of translocation with breakpoints in heterochromatic regions of human chromosomes. |
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