A natural prodrug activation mechanism in nonribosomal peptide synthesis |
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| Authors: | Reimer Daniela Pos Klaas M Thines Marco Grün Peter Bode Helge B |
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| Affiliation: | Molecular Biotechnology, Institute for Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany. |
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| Abstract: | We have identified a new mechanism for the cleavage and activation of nonribosomally made peptides and peptide-polyketide hybrids that are apparently operational in several different bacteria. This process includes the cleavage of a precursor molecule by a membrane-bound and D-asparagine-specific peptidase, as shown here in the biosynthesis of the antibiotic xenocoumacin from Xenorhabdus nematophila. |
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