Venlafaxine Modulates Depression-Induced Oxidative Stress in Brain and Medulla of Rat |
| |
Authors: | ?brahim Eren Mustafa Naz?ro?lu Arif Demirda? Ömer Çelik A Cihangir U?uz Ay?e Altunba?ak ?smail Özmen Efkan Uz |
| |
Institution: | (1) Department of Psychiatry, Medical Faculty, Suleyman Demirel University, Isparta, Turkey;(2) Department of Biophysics, Medical Faculty, Suleyman Demirel University, Postakutusu 68 Cunur, 32260 Isparta, Turkey;(3) Department of Medical Biology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey;(4) Department of Chemistry, Art and Science Faculty, Suleyman Demirel University, Isparta, Turkey |
| |
Abstract: | Venlafaxine is an approved antidepressant that is an inhibitor of both serotonin and norepinephrine transporters. Medical
treatment with oral venlafaxine can be beneficial to depression due to reducing free radical production in the brain and medulla
of depression- induced rats because oxidative stress may a play role in some depression. We investigated the effect of venlafaxine
administration and experimental depression on lipid peroxidation and antioxidant levels in cortex brain, medulla and erythrocytes
of rats. Thirty male wistar rats were used and were randomly divided into three groups. Venlafaxine (20 mg/kg) was orally
supplemented to depression-induced rats constituting the first group for four week. Second group was depression-induced group
although third group was used as control. Depressions in the first and second groups were induced on day zero of the study
by chronic mild stress. Brain, medulla and erythrocytes samples were taken from all animals on day 28. Depression resulted
in significant decrease in the glutathione peroxidase (GSH-Px) activity and vitamin C concentrations of cortex brain, glutathione
(GSH) value of medulla although their levels were increased by venlafaxine administration to the animals of depression group.
The lipid peroxidation levels in the three tissues and nitric oxide value in cortex brain elevated although their levels were
decreased by venlafaxine administration. There were no significant changes in cortex brain vitamin A, erythrocytes vitamin
C, GSH-Px and GSH, medulla vitamin A, GSH and GSH-Px values. In conclusion, cortex brain within the three tissues was most
affected by oxidative stress although there was the beneficial effect of venlafaxine in the brain of depression-induced rats
on investigated antioxidant defenses in the rat model. The treatment of depression by venlafaxine may also play a role in
preventing oxidative stress.
Abstract of the paper was submitted in 1st Ion Channels and Oxidative Stress Congress, 14–16 September 2006, Isparta, Turkey. |
| |
Keywords: | Venlafaxine Depression Antioxidant Oxidative stress ·Chronic mild stress |
本文献已被 PubMed SpringerLink 等数据库收录! |
|