CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine |
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Authors: | Guo Xiaoyu Jia Hong Zhang Quan Yuan Weifeng Zhu Gang Xin Ting Zhu Hongfei Sánchez-Vizcaíno José Manuel |
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Affiliation: | Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China. |
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Abstract: | A CpG-enriched recombinant plasmid (pUC18-CpG) as an adjuvant of FMD killed vaccine was tested for immunization and vaccination challenge in a porcine model. Our preliminary results had indicated that the recombinant plasmid could enhance the humoral immune response triggered by the traditional oil-adjuvant vaccine after the initial inoculation. A subsequent vaccination-challenge test showed an increased PD(50) value. Thus, coadministration of the recombinant plasmid with the oil-adjuvant vaccine helped illicit an immune response earlier than that elicited by giving the vaccine alone. Our results showed that pUC18-CpG can be a potent immunoadjuvant for the traditional FMD killed vaccine and can greatly enhance the traditional vaccine's efficacy when given in combination with it. |
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Keywords: | CpG motif efficacy foot‐and‐mouth disease (FMD) killed vaccine immunoadjuvant |
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