Amphetamine inhibition of alpha-bungarotoxin binding at the mouse neuromuscular junction. |
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Authors: | K A Skau M C Gerald |
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Affiliation: | Division of Pharmacology, College of Pharmacy Ohio State University Columbus, Ohio 43210, USA |
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Abstract: | Amphetamine inhibited neuromuscular transmission and prevented the irreversible blockade produced by α-bungarotoxin (α-BGT) in the isolated mouse phrenic nerve-diaphragm preparation. Similarly, amphetamine (1.35 × 10?4 to 3 × 10?3M) inhibited the binding of 125I-α-BGT to mouse hemidiaphragms in a concentration-dependent manner; (+)-amphetamine was found to be twice as potent as its (-)-isomer with respect to inhibition of 125I-α-BGT binding. It is suggested that amphetamine binds to the nicotinic, cholinergic receptor of skeletal muscle and may produce weakness and paralysis in amphetamine overdosage. |
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Keywords: | To whom reprint requests should be addressed. |
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