酸敏感离子通道外源性配体研究进展

酸敏感离子通道(ASICs)属于上皮 Na+ 通道/退化蛋白超家族,对细胞外 H+ 浓度变化敏感,其受多种外源性配体调控,产生 不同生理和病理学效应。越来越多研究发现,ASICs 参与脑缺血、炎症、肿瘤等具有酸化改变的病理过程。简介 ASICs 的结构及其配体 作用位点以及各亚基的组织分布和电生理特性,主要对各类 ASICs 外源性配体的研究进展作一综述。

Research Progress on the Exogenous Ligands of Acid-sensing Ion Channels

Acid-sensing ion channels(ASICs) belong to the epithelial Na+-channels(ENaC)/degenerin(DEG) family, which are activated by extracellular acidosis and regulated by a variety of exogenous ligands, leading to different physiological and pathological consequences. Recent studies have demonstrated that ASICs are involved in cerebral ischemia, in ammation, tumor, and other pathological processes associated with extracellular acidi cation. In this paper, the structure of ASICs and action sites of their exogenous ligands as well as the tissue distributions and electrophysiological characteristics of the subunits were introduced, and the research progress on various types of the exogenous ligands of ASICs was emphatically reviewed.