| 基于分子对接的小分子 c-Met 抑制剂结构特征及其研究进展 |
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| 引用本文： | 耿晓婷. 基于分子对接的小分子 c-Met 抑制剂结构特征及其研究进展[J]. 微生物学杂志, 2016, 0(2) |
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| 作者姓名： | 耿晓婷 |
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| 作者单位： | 中国药科大学有机化学教研室，江苏 南京 210009 |
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| 摘 要： | 受体酪氨酸激酶 c-Met 是抗肿瘤治疗的一个重要靶点，c-Met/HGF 通路在肿瘤的发生、发展、转移及血管再生中发挥重要作用。综述 c-Met 及与配体 HGF 的复合物结构特征、c-Met/HGF 通路的生物学作用以及靶向 c-Met 抗肿瘤小分子抑制剂的研究进展。
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| 关 键 词： | HGF/c-Met 通路；c-Met 抑制剂；分子对接；肿瘤 |
Molecular Docking-based Structure Characteristics andResearch Advances of Small Moleculec-Met Kinase Inhibitors |
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| GENG Xiaoting. Molecular Docking-based Structure Characteristics andResearch Advances of Small Moleculec-Met Kinase Inhibitors[J]. Journal of Microbiology, 2016, 0(2) |
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| Authors: | GENG Xiaoting |
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| Affiliation: | Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Receptor tyrosine kinase c-Met is an important target in anti-tumor therapy. HGF/c-Met signaling pathway is strongly implicated inthe formation, development, metastasis and angiogenesis of tumor. The structural characteristics of c-Met and c-Met-HGF complex, the biologicalfunctions of c-Met/HGF signaling pathway, and the advances in small molecule c-Met kinase inhibitors were reviewed in this article. |
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| Keywords: | HGF/c-Met signaling pathway c-Met inhibitor molecular docking tumo |
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