| 天然来源的乙型和丙型肝炎病毒抑制剂的研究进展 |
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| 引用本文： | 姜坤. 天然来源的乙型和丙型肝炎病毒抑制剂的研究进展[J]. 微生物学杂志, 2016, 0(1) |
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| 作者姓名： | 姜坤 |
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| 作者单位： | 中国科学院上海药物研究所天然药物化学研究室，上海 201203 |
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| 基金项目： | 国家自然科学基金 (No. 81072545; No.21202182)；国家重大科技专项“重大新药创制”(No. 2012ZX09304-011) |
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| 摘 要： | 慢性病毒性肝炎是威胁人类健康的主要流行病之一，目前全球约有 4 亿慢性乙型和丙型肝炎患者，现有临床药物仍不能很好地治愈病毒性肝炎。作为药物发现的重要来源，天然产物提供了许多能强效抑制乙型肝炎病毒 (hepatitis B virus, HBV) 和丙型肝炎病毒（hepatitisC virus, HCV）的抑制剂。综述近 10 年来国内外报道的抗 HBV 和 HCV 的活性中药成分和天然产物的研究进展。
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| 关 键 词： | 有毒动物；毒素；离子通道；受体 |
Research Progress in Natural Inhibitors againstHepatitis B and C Viruses |
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| JIANG Kun. Research Progress in Natural Inhibitors againstHepatitis B and C Viruses[J]. Journal of Microbiology, 2016, 0(1) |
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| Authors: | JIANG Kun |
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| Abstract: | Chronic viral hepatitis is one of the major epidemics that pose a huge threat to human health. There are about 400 million patientssuffering from chronic hepatitis B and C worldwide, which are not adequately cured by currently available drugs. Natural products, as an importantsource of drug discovery, offer many potent inhibitors against hepatitis B and C viruses. This paper reviewed the research progress in traditional Chinesemedicine ingredients and natural products against HBV and HCV in the last decade. |
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| Keywords: | chronic viral hepatitis anti-HBV anti-HCV natural product |
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