CXCR7 的生物学功能及其在肿瘤发生发展中的 作用研究进展

趋化因子受体是一类G 蛋白偶联的7 次跨膜受体，其与配体结合能参与调控多种生理和病理学过程。以往，CXCR4 一直被认为 是趋化因子CXCL12 的唯一受体。然而近年来的研究表明CXCL12 能与另一种新受体CXCR7 结合，并在调控肿瘤转移、血管生成和细 胞粘附等方面起着重要作用，CXCR7 由此成为肿瘤治疗的潜在靶点。介绍CXCR7 的结构、生物学功能以及CXCR7 在肿瘤发生发展中 的作用。

Advances in Research on Biological Functions of CXCR7 and Its Involvement in Carcinogenesis and Progression

Chemokine receptor, a kind of G-protein-coupled seven-span transmembrane receptors (7-TMRs), binds to specific ligands and regulates a variety of physical and pathological processes. Previously, CXCR4 was regarded as the only receptor of CXCL12. However, recent work has demonstrated that CXCL12 also binds to another new receptor (CXCR7), and plays a major role in regulating metastasis, angiogenesis and cell adhesion. Thus, CXCR7 emerges as a potential target for cancer therapy. The structure, ligands and biological functions of CXCR7, as well as the its involvement in carcinogenesis and progression were introduced in this paper.