| 大环内酯类9 位羰基结构修饰衍生物的研究进展 |
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| 引用本文： | 王绍菊. 大环内酯类9 位羰基结构修饰衍生物的研究进展[J]. 微生物学杂志, 2016, 0(7) |
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| 作者姓名： | 王绍菊 |
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| 作者单位： | 中国药科大学药物化学教研室,江苏 南京 210009 |
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| 摘 要： | 大环内酯类抗生素自上市以来一直用于治疗呼吸系统等疾病,但随着该类药物的广泛应用,耐药菌日益增多。为此,研究者们一直致力于半合成大环内酯类抗生素的研究,希望开发出对耐药菌有效、抗菌谱广的半合成衍生物。综述近年来对大环内酯9 位羰基结构修饰的研究进展,并着重介绍一些活性较好的化合物。
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| 关 键 词： | 红霉素 9 位结构修饰 肟醚 成环修饰 抗菌活性 |
Progress in Macrolide Derivatives with C9- CarbonylModification |
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| WANG Shaoju. Progress in Macrolide Derivatives with C9- CarbonylModification[J]. Journal of Microbiology, 2016, 0(7) |
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| Authors: | WANG Shaoju |
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| Affiliation: | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Macrolide antibiotics have been used to treat respiratory and other infectious diseases since they were launched. However, their wideapplication have led to the increase in resistant strains of bacteria. Therefore, researchers have been concentrating on the investigation of semi-syntheticmacrolide antibiotics, hoping to develop semi-synthetic derivatives with activity against resistant bacteria and broad antibacterial spectrum. The recentresearch progress in structure modification of C9-carbonyl of macrolide was reviewed, and some compounds with superior activity were highlighted aswell. |
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| Keywords: | erythromycin C9-structure modification oxime ether ring modification antibacterial activity |
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