Space-filling effects in membrane disruption by cationic amphiphiles |
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| Authors: | Fujiwara T Hirashima N Hasegawa S Nakanishi M Ohwada T |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. |
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| Abstract: | We studied the hemolytic activity towards bovine erythrocytes of novel synthetic steroid-polyamine conjugates consisting of a rigid hydrophobic steroid unit, and a flexible hydrophilic polyamine unit connected by a linker. The steroid structure, polyamine chain length, and the presence of a hydrophobic substituent on the steroid, all influenced the activity. Analysis of the time dependence of hemolysis suggested that these structurally related cationic amphiphiles have different mechanisms of membrane perturbation. |
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