Stability of (2'-5')oligoriboadenylates in various sera |
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| Authors: | S Vilcek O J Vrtiak J Smrt M Jurovcík |
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| Institution: | 1. Department of Infectology, University of Veterinary Medicine, Komenského 73, CS-04000 Ko?ice, Czechoslovakia;2. Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 16610 Prague, Czechoslovakia;3. Institute of Molecular Genetics, Czechoslovak Academy of Sciences, 16637 Prague 6, Czechoslovakia |
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| Abstract: | Avian and mammalian sera were found to contain an enzyme activity degrading 2-5A oligonucleotides. The most extensive degradation of the A2' p5' A was observed in chicken serum. Degradation of this compound is not affected by the presence of cAMP, dsRNA, Mg2+, but is significantly inhibited by EDTA. The enzyme activity described is not inactivated by heating to 56 degrees C for 30 min. The 5-mU3' p5' A has also been degraded in chicken serum. |
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| Keywords: | (2′–5′)Oligoriboadenylate Serum Phosphodiesterase Interferon action |
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