Cell-cell communication in Gram-negative bacteria |
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Authors: | Welch Martin Mikkelsen Helga Swatton Jane E Smith Debra Thomas Gemma L Glansdorp Freija G Spring David R |
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Institution: | Department of Biochemistry, University of Cambridge, Cambridge, UK. |
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Abstract: | Over the last decade or so, a wealth of research has established that bacteria communicate with one another using small molecules. These signals enable the individuals in a population to coordinate their behaviour. In the case of pathogens, this behaviour may include decisions such as when to attack a host organism or form a biofilm. Consequently, such signalling systems are excellent targets for the development of new antibacterial therapies. In this review, we assess how Gram-negative bacteria use small molecules for cell-cell communication, and discuss the main approaches that have been developed to interfere with it. |
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