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The chemical structure of prostaglandin X (prostacyclin). |
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| Authors: | N Whittaker S Bunting J Salmon S Moncada J R Vane R A Johnson D R Morton J H Kinner R R Gorman J C McGuire F F Sun |
| Abstract: | The chemical structure of prostaglandin X, the anti-aggregatory substance derived from prostaglandin endoperoxides, is 9-deoxy-6, 6alpha-epoxy-delta5-PGF1alpha. The stable compound formed when prostaglandin X undergoes a chemical transformation in biological systems in 6-keto-PGF1alpha. Prostaglandin X is stabilized in aqueous preparations by raising the pH to 8.5 or higher. The trivial name prostacyclin is proposed for 9-deoxy-6, 9alpha-epoxy-delta5-PGF1alpha. |
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