Herbal remedies traditionally used against malaria in Ghana: bioassay-guided fractionation of Microglossa pyrifolia (Asteraceae) |
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Authors: | Köhler Inga Jenett-Siems Kristina Kraft Carola Siems Karsten Abbiw Daniel Bienzle Ulrich Eich Eckart |
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Institution: | Institut für Pharmazie (Pharmazeutische Biologie), Freie Universit?t Berlin, K?nigin-Luise-Strasse 2+4, D-14195 Berlin, Germany. |
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Abstract: | Different extracts from 11 West African plants traditionally used against malaria in Ghana were tested against both the chloroquine-sensitive strain PoW and the chloroquine-resistant clone Dd2 of Plasmodium falciparum. Due to the promising in vitro activity of the lipophilic extract IC50: 10.5 microg/ml (PoW); 13.1 microg/ml (Dd2)], Microglossa pyrifolia (Lam.) Kuntze (Asteraceae) was chosen for further phytochemical investigation. From active fractions 13 compounds were isolated; their structures were established on the basis of spectroscopic methods. 1-Acetyl-6E-geranylgeraniol-19-oic acid and sinapyl diangelate represent new natural compounds. The two diterpenes E-phytol IC50: 8.5 microM (PoW); 11.5 microM (Dd2)], and 6E-geranylgeraniol-19-oic acid IC50: 12.9 microM (PoW); 15.6 microM (Dd2)] proved to be the most active constituents in our test system. |
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