Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium |
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Authors: | Ognjanovi? B I Pavlovi? S Z Maleti? S D Ziki? R V Stajn A S Radojici? R M Saici? Z S Petrovi? V M |
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Institution: | Institute of Biology, Faculty of Sciences, University of Kragujevac, Radoja Domanovi?a 12, P.O. Box 60, 34000 Kragujevac, Serbia, Yugoslavia. branka@knez.uis.kg.ac.yu |
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Abstract: | The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system, lipid peroxide concentration and hematological parameters, as well as the possible protective role of vitamin E were studied. Male Wistar albino rats (3 months old) were treated with cadmium (0.4 mg Cd/kg b.m., i.p., 24 h before the experiment) or with vitamin E + Cd (20 IU Vit E/kg b.m., i.m., 48 h + 0.4 mg Cd/kg b.m., i.p., 24 h before the experiment). The hematological parameters were assessed: red blood cell counts, hematocrit value and hemoglobin concentration were significantly decreased in the blood of Cd-treated rats. Intoxication with cadmium was also followed by significantly increased lipid peroxide concentrations. We also observed increased activity of antioxidant defense enzymes: copper zinc containing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase as well as concentrations of non-enzymatic components of antioxidant defense system: reduced glutathione, vitamin C and vitamin E. Pretreatment with vitamin E exhibited a protective role on the toxic effects of cadmium on the hematological values, lipid peroxide concentration as well as on enzymatic and non-enzymatic components of antioxidant defense system. |
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