Chemicals isolated from Justicia adhatoda Linn reduce fitness of the mosquito,Aedes aegypti L |
| |
| Authors: | Annamalai Thanigaivel Sengottayan Senthil‐Nathan Prabhakaran Vasantha‐Srinivasan Edward‐Sam Edwin Athirstam Ponsankar Selvaraj Selin‐Rani Venkatraman Pradeepa Muthiah Chellappandian Kandaswamy Kalaivani Ahmed Abdel‐Megeed Raman Narayanan Kadarkarai Murugan |
| |
| Institution: | 1. Division of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India;2. Post Graduate and Research Centre, Department of Zoology, Sri Parasakthi College for Women, Tirunelveli, Tamil Nadu, India;3. Department of Plant Protection, Faculty of Agriculture, Saba Basha, Alexandria University, Alexandria, Egypt;4. Department of Zoology, Sri Paramakalyani College, Tirunelveli, Tamil Nadu, India;5. Thiruvalluvar University, Vellore, Tamil Nadu, India |
| |
| Abstract: | Extracts from Justicia adhatoda L. (Acanthaceae) strongly reduced the fitness of the mosquito, Aedes aegypti Linn. The methanolic extracts inhibited several enzymes responsible for protecting insects from oxidative and other damage, including glutathione‐S‐transferase, superoxide dismutase, cytochrome P450, and α‐ and β‐esterases. They increased repellency (maximum repellency at 100 ppm) in host‐seeking adult females using the “arm‐in cage assay.” Histopathological examination showed the extracts led to serious midgut cell damage. Justicia adhatoda extracts led to reduced fecundity and oviposition of gravid females compared to controls. The extracts led to substantially reduced A. aegypti survival. We infer that the extracts have potential to reduce pathogen transmission by suppressing population growth of A. aegypti, and possibly other mosquito species. |
| |
| Keywords: | botanical insecticide deterrent enzyme inhibition histology metabolites mosquito oviposition |
|
|
