Oxidation of pyrimidine bases and their derivatives by sodium peroxodisulfate |
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Authors: | T Itahara N Ide A Nishino |
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Affiliation: | Institute of Chemistry, College of Liberal Arts, Kagoshima University, Japan. |
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Abstract: | Treatment of 1,3-dimethyluracil (1) with sodium peroxodisulfate in water at 80 degrees C under nitrogen gave 5-hydroxy-1,3-dimethyluracil (6) as a main product. Under similar conditions, oxidation of 5-fluoro-1,3-dimethyluracil (2) gave a 6,6'-dimeric compound (10) together with other products. Similar oxidation of 5-bromo-1,3-dimethyluracil (3) and 1,3,6-trimethyluracil (4) was also investigated. Furthermore, reaction of 1,3-dimethylthymine (5) and adenine in the presence of sodium peroxodisulfate gave coupling products (12) and (13). |
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