Limitations of enzymatic acylation using oxime esters: Cosubstrate inhibition and the reversibility of the reaction |
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Authors: | M Mischitz U Pöschl K Faber |
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Institution: | (1) Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16, A-8010 Graz, Austria |
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Abstract: | Summary Enzymatic resolution of (±)-endo-bicyclo2.2.1]hept-5-en-2-ol (1a) catalysed byCandida cylindracea lipase using either acetoneoxime acetate (2a) or biacetyldioxime diacetate (3a) as acyl donor proceeds with moderate to good enantioselectivity (E=13 and 22, resp.) although clear limitations of this method are observed: firstly, a severe depletion of the reaction rate at elevated cosubstrate (acyl donor) concentrations and secondly, the reversibility of the reaction. |
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