Limited genetic diversity in polynesians reflected in the highly polymorphic 3'HVR alpha-globin gene marker. |
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| Authors: | M S Hertzberg K N Mickleson R J Trent |
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| Affiliation: | Department of Molecular Genetics, Royal Prince Alfred Hospital, Camperdown, N.S.W., Australia. |
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| Abstract: | Polynesians from five distinct island groups were studied with DNA probe alpha 3'HVR, a highly polymorphic VNTR (variable number of tandem repeats) minisatellite region associated with the alpha-globin gene cluster. Results showed a paucity of genetic heterozygosity together with clustering of alpha 3'HVR alleles with alpha-globin DNA haplotypes and alpha-globin gene rearrangements. This restricted diversity is consistent with population bottlenecks in the colonization of Polynesia. |
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