mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin |
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Authors: | Mizobe Yurika Oikawa Daichi Tsuyama Shoichiro Akimoto Yoriko Hamasu Kousuke Onitsuka Eiichiro Sato Mikako Takahata Yoshihisa Morimatsu Fumiki Furuse Mitsuhiro |
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Affiliation: | Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuaka-shi, Japan. |
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Abstract: | Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period. |
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