BTB/POZ domain of speckle-type POZ protein (SPOP) confers proapoptotic function in HeLa cells |
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Authors: | Byun Boohyeong Tak Heejae Joe Cheol O |
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Affiliation: | Department of Oriental Medicine, Daegu Haany University, Daegu, South Korea. bhbyun@dhu.ac.kr |
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Abstract: | The proapoptotic function of SPOP protein was investigated in HeLa cells. HeLa cells underwent apoptosis by the overexpression of SPOP. Studies using SPOP deletion mutants suggest that BTB/POZ domain of SPOP protein is important for the induction of apoptosis in transfected cells. This study first proposes the proapoptotic aspect of the BTB/POZ domain of SPOP protein based on the finding that cells expressing the C-terminal fragment of SPOP containing the BTB/POZ domain underwent apoptosis. |
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