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In vitro delivery of curcumin with cholesterol-based cationic liposomes |
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| Authors: | N. Apiratikul T. Penglong K. Suksen S. Svasti A. Chairoungdua B. Yingyongnarongkul |
| Affiliation: | 16491. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok, 10240, Thailand 26491. Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhonpathom, 73170, Thailand 36491. Department of Physiology, Mahidol University, Bangkok, 10400, Thailand 46491. Research Center of Transport Proteins for Medical Innovation, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand |
| Abstract: | A new cholesterol-based cationic lipid was synthesized; liposomes prepared on its basis were evaluated as drug delivery vehicles for curcumin. Free and liposome-encapsulated curcumin cytotoxicity against HeLa, A549, HepG2, K562 and 1301 cell lines was assessed. Liposomal curcumin with ED50 values ranging from 2.5–10 μM exhibited 2–8 times higher cytotoxicity than free curcumin. The synthetic cholesterol-based cationic lipid also enhanced cellular uptake of curcumin into tested cells. Cationic liposome alone showed low cytotoxicity at high doses with ED50 values of 90–210 μM. |
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