Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes |
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| Authors: | S Adamo B M Zani C Nervi M I Senni M Molinaro F Eusebi |
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| Affiliation: | Institute of Histology and General Embryology. University of Rome, via A. Scarpa 14,00161 Rome, Italy |
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| Abstract: | Acetylcholine treatment of [3H]inositol pre-labelled cultured chick embryo myotubes results in the stimulation of phosphatidylinositol breakdown, as shown by the measurement of inositol-1-phosphate accumulating in the presence of lithium. The described effect is dependent on agonist concentration and incubation time, and is inhibited by tubocurarine and alpha-bungarotoxin. The activation of phosphatidylinositol breakdown by acetylcholine at extrajunctional nicotinic receptors is likely to be involved in the modulation of the functional activity of the receptor. |
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