Synthesis and antiviral activity of ureides and carbamates of betulinic acid and its derivatives |
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| Authors: | Flekhter O B Boreko E I Nigmatullina L R Tret'iakova E V Pavlova N I Baltina L A Nikolaeva S N Savinova O V Galin F Z Tolstikov G A |
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| Institution: | Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia. obf@anrb.ru |
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| Abstract: | Ureides and carbamates of betulinic acid and its derivatives were prepared in good yields by interaction of betulinic acid, betulonic acid, and betulonic acid 3-oxime with amines, amino acids, and alcohols. Ureides of betulonic acid containing L-Val and L-Met residues were found to be effective against herpes simplex type 1 virus. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2003, vol. 29, no. 6; see also http://www.maik.ru. |
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