| 人类Y染色体长臂异染色质区与鱼类基因组的比较分析 |
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| 引用本文： | 易梅生,余其兴,郭一清,刘利,周荣家.人类Y染色体长臂异染色质区与鱼类基因组的比较分析[J].动物学报,2002,48(1):135-138. |
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| 作者姓名： | 易梅生 余其兴 郭一清 刘利 周荣家 |
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| 作者单位： | 武汉大学生命科学学院,武汉,430072 |
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| 基金项目： | 国家自然科学基金，39770407， |
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| 摘 要： | 脊椎动物有一些共同特征,这些共有性状都是在漫长的进化历程中保留下来的,因而极具保守性.这种进化上性状的保守性反映了它们的基因组结构存在一定的保守性.人类和硬骨鱼类在进化地位上相差甚远,正因如此,它们基因组之间的保守结构才真实代表了脊椎动物进化的最本质特征.因此,以斑马鱼( Dario rerio )和河豚等鱼类模式物种与人类之间直接开展比较基因组研究是近年来的国际学术探讨热点之一(Amores et al .,1998; Meyer et al .,1998).
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| 关 键 词： | 人类 Y染色体长臂 异染色质 鱼类基因组 荧光原位杂交 比较分析 |
GENOMIC COMPARATIVE ANALYSIS BETWEEN THE HUMAN Y CHROMOSOME-SPECIFIC HETEROCHROMATIN REGION AND FISH GENOMES |
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| YI Mei-Sheng YU Qi-Xing,- GUO Yi-Qing LIU Li ZHOU Rong-Jia.GENOMIC COMPARATIVE ANALYSIS BETWEEN THE HUMAN Y CHROMOSOME-SPECIFIC HETEROCHROMATIN REGION AND FISH GENOMES[J].Acta Zoologica Sinica,2002,48(1):135-138. |
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| Authors: | YI Mei-Sheng YU Qi-Xing - GUO Yi-Qing LIU Li ZHOU Rong-Jia |
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| Institution: | YI Mei-Sheng YU Qi-Xing **- GUO Yi-Qing LIU Li ZHOU Rong-Jia |
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| Abstract: | The repeated DNA in the genomes of three fish species (Dario rerio, Monopterus albus and Mastacembelus aculeatus), were compared with those in human Y chromosome-specific heterochromatin by genomic comparative in situ hybridization.The results showed that the repeated DNA in the genomes of three fish species could not hybridize with those in human Y chromosome-specific heterochromatin region and the human Y chromosome had its specific repeated DNA sequence.Some problems about the evolution of the repeated DNA in human Y chromosome-specific heterochromatin region were discussed. |
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| Keywords: | Human Y chromosome Heterochromatin Fish genomes Genomic comparison Fluorescence in situ hybridization |
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