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Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors |
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| Authors: | Varaprasad Chamakura V N S Barawkar Dinesh El Abdellaoui Hassan Chakravarty Subrata Allan Matthew Chen Huanming Zhang Weijian Wu Jim Z Tam Robert Hamatake Robert Lang Stanley Hong Zhi |
| Affiliation: | Drug Discovery, Valeant Pharmaceutical Research and Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. vchamakura@valeant.com |
| Abstract: | 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors. |
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