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Decreased CD8 |
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| Authors: | Michael P Pender Peter A Csurhes Casey MM Pfluger Scott R Burrows |
| Affiliation: | (1) School of Medicine, Health Sciences Building, Royal Brisbane and Women’s Hospital, The University of Queensland, Queensland, 4029, Australia;(2) Department of Neurology, Royal Brisbane and Women’s Hospital, Queensland, 4029, Australia;(3) The University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, Queensland, 4029, Australia;(4) Cellular Immunology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd., Brisbane, 4029, Australia |
| Abstract: | BackgroundPatients with multiple sclerosis (MS) have a decreased frequency of CD8+ T cells reactive to their own Epstein-Barr virus (EBV) infected B cells. We have proposed that this might predispose to the development of MS by allowing EBV-infected autoreactive B cells to accumulate in the central nervous system. The decreased CD8+ T cell response to EBV results from a general CD8+ T cell deficiency and also a decreased proportion of EBV-specific T cells within the total CD8+ T cell population. Because decreased HLA class I expression on monocytes and B cells has been reported in MS and could influence the generation and effector function of EBV-specific CD8+ T cells, the present study was undertaken to measure the expression of HLA molecules on B cells and monocytes in patients with MS. |
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