Exosome-based immunotherapy |
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Authors: | Nathalie?Chaput Julien?Ta?eb No?l?E?C?Schartz Fabrice?André Eric?Angevin Email author" target="_blank">Laurence?ZitvogelEmail author |
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Institution: | (1) ERIT-M 02-08 INSERM, Department of Clinical Biology, Institut Gustave Roussy (IGR), 39 rue Camille Desmoulins, 94805 Villejuif, France;(2) Department of Hepatology and Gastroenterology, Pitié Salpétrière Hospital, Paris, France;(3) Department of Dermatology, Saint Louis Hospital, Paris, France;(4) Department of Medical Oncology, Institut Gustave Roussy (IGR), Villejuif, France |
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Abstract: | Exosomes are small membrane vesicles originating from late endosomes and secreted by hematopoietic and epithelial cells in culture. Exosome proteic and lipid composition is unique and might shed some light into exosome biogenesis and function. Exosomes secreted from professional antigen-presenting cells (i.e., B lymphocytes and dendritic cells) are enriched in MHC class I and II complexes, costimulatory molecules, and hsp70–90 chaperones, and have therefore been more extensively studied for their immunomodulatory capacities in vitro and in vivo. This review will present the main biological features pertaining to tumor or DC-derived exosomes, will emphasize their immunostimulatory function, and will discuss their implementation in cancer immunotherapy.Abbreviations APC
antigen-presenting cell
- ASI
active specific immunotherapy
- CTL
cytotoxic T lymphocyte
- DC
dendritic cell
- FDC
follicular dendritic cell
- MD-DC
monocyte-derived dendritic cell
- GMP
good manufacturing procedure
- HLA
human leukocyte antigen
- HSP
heat shock protein
- MHC
major histocompatibility complex
- MVB
multivesicular body
- ExAs
ascitis-derived exosomes
- DEX
DC-derived exosome
- TEX
tumor cell–derived exosome
This work was presented at the first Cancer Immunology and Immunotherapy Summer School, 8–13 September 2003, Ionian Village, Bartholomeio, Peloponnese, Greece. |
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Keywords: | Exosomes Cross-presentation MHC complexes Tumor Immunotherapy |
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