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Absolute configuration of (+)-pinoresinol 4-O-[6″-O-galloyl]-β-d-glucopyranoside, macarangiosides E, and F isolated from the leaves of Macaranga tanarius
Authors:Katsuyoshi Matsunami  Hideaki Otsuka  Kazunari Kondo  Takakazu Shinzato  Masatoshi Kawahata  Kentaro Yamaguchi  Yoshio Takeda
Abstract:A lignan glucoside, (+)-pinoresinol 4-O-6″-O-galloyl]-β-d-glucopyranoside (1), and two megastigmane glucosides, named macarangiosides E and F (2, 3), together with 15 known compounds (418) were isolated from leaves of Macaranga tanarius (L.) Müll.-Arg. (Euphorbiaceae). Their structures were elucidated by spectroscopic and chemical analyses. In addition, the absolute stereochemistry of macarangiosides B and C isolated previously from the same plant was also determined for the first time. Compounds 1 and 2 were galloylated on glucose and possessed potent DPPH radical-scavenging activity.
Keywords:Macaranga tanarius  Euphorbiaceae  Lignan  Megastigmane  DPPH  Cytotoxicity
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