Fractionation and anti-tumor activity of the mycelia of liquid-cultured Phellinus linteus |
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Authors: | Nakamura Tomoyuki Matsugo Seiichi Uzuka Yasuyuki Matsuo Sumitaka Kawagishi Hirokazu |
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Institution: | Applied Fungi Institute, IBI Corporation, Yamanashi, Japan. n-tomo@comlink.ne.jp |
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Abstract: | All the fractions of Phellinus linteus mycelia showed anti-tumor activity toward solid tumors planted in mice. The highest anti-tumor activity of 81.2% was observed in the protein-glucan complex obtained by precipitating the 24% NaOH extract at pH 6.0. This protein-glucan complex consisted of 39.3% polysaccharide and 49.4% protein. Its (13)C- and (1)H-NMR data showed that the main glucan part of the complex was simple alpha-1,3-glucan chains. |
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