Expressions of receptor gene for hepatocyte growth factor in kidney after unilateral nephrectomy and renal injury. |
| |
| Authors: | K Ishibashi S Sasaki H Sakamoto Y Hoshino T Nakamura F Marumo |
| |
| Institution: | Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan. |
| |
| Abstract: | The renal expressions of the receptor gene (c-met) for hepatocyte growth factor (HGF) were examined in unilateral nephrectomy (UNX), renal ischemia or folic acid administration. The levels of c-met mRNA were increased rapidly in all rat models at 6h after the operations. On the other hand, the expression of c-met mRNA in a kidney cell line (MDCK cells) was down-regulated for 8 h after HGF addition, indicating that c-met mRNA induction in rat models may be independent of the stimulated production of HGF. The stimulated expression of c-met in these models suggest that HGF may play an important role in renal hypertrophy after UNX and regeneration after ischemic or nephrotoxic injury. |
| |
| Keywords: | |
|
|
