The development of the muscarinic acetylcholine receptor in normal and hyperphenylalaninemic rat cerebrum |
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Authors: | Kiyosato Matsuo Frits A. Hommes |
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Affiliation: | (1) Department of Cell and Molecular Biology, Medical College of Georgia, 30912-2100 Ugusta, GA |
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Abstract: | The effect of hyperphenylalaninemia on the development of the muscarinic acetylcholine receptor in rat cerebrum has been studied. Rats were subjected to the hyperphenylalaninemic regimen as of 5 days of age. A gradual and steady decrease in the number of binding sites forl-[3H]quinuclidinylbenzilate was observed, with the white matter more affected than the gray matter. A return to normal blood phenylalanine levels after the age of 21 days does not lead to an increase in this number of binding sites. |
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Keywords: | Muscarinic acetylcholine receptor development hyperphenylalaninemia |
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