The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: hydroxyindole derivatives |
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| Authors: | Milkiewicz K L Marsilje T H Woodworth R P Bifulco N Hangauer M J Hangauer D G |
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| Institution: | Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, 14260-1200, USA. |
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| Abstract: | As part of a continuing effort to identify novel scaffolds that inhibit the pp60(c-src) protein tyrosine kinase, a series of hydroxyindole amides was rationally designed and synthesized. The most potent derivative was found to bind non-competitively with respect to ATP. |
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