Synthesis and cytotoxic activity of novel C7-functionalized spongiane diterpenes |
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Authors: | Arnó Manuel Betancur-Galvis Liliana González Miguel A Sierra Jelver Zaragozá Ramón J |
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Affiliation: | Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Valencia, Spain. |
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Abstract: | Based on two lead cytotoxic spongiane diterpenes, a new series of C7-oxygenated derivatives were synthesized and evaluated for their antitumor activity in vitro against the cancer cell lines HeLa and HEp-2. In general, introduction of either hydroxyl or acetoxy groups at C-7 did not improve the resultant cytotoxicity, while the presence of a butyrate ester led to more active compounds (CC(50)=4.0-9.5 microM). |
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