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How to activate p53 |
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| Authors: | Caspari T |
| Affiliation: | MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK. T.Caspari@sussex.ac.uk |
| Abstract: | The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20. |
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