Muscarinic receptor-mediated intracellular Ca mobilization in embryonic chick heart cells |
| |
Authors: | H Schmidt G Oettling U Drews |
| |
Affiliation: | Anatomisches Institut der Universit?t Tübingen, FRG. |
| |
Abstract: | Activation of muscarinic receptors of heart cells elevates the intracellular Ca2+ concentration. The increase is considered to be due to influx of extracellular Ca2+. We show that intracellular Ca2+ mobilization is involved. Cell suspensions prepared from hearts of 6-day-old chick embryos were loaded with the fluorescent Ca2+ chelator chlortetracycline. Muscarinic stimulation induces a dose-dependent fluorescence decrease (ED50=2.6 × 10−6 M) indicating intracellular Ca2+ mobilization. |
| |
Keywords: | Ca2+ mobilization Muscarinic receptor Chlortetracycline (Chick heart) |
本文献已被 ScienceDirect 等数据库收录! |