首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancer
Authors:Osamu Nunobiki  Masatsugu Ueda  Michiko Yamamoto  Eisaku Toji  Naomi Sato  Shinji Izuma  Yoshiaki Okamoto  Kiyo Torii  Sadamu Noda
Institution:Department of Medical Technology, Kobe Tokiwa University, Hyogo,;Cytopathology and Gynecology, Osaka Cancer Prevention and Detection Center,;Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Abstract:Genetic polymorphisms of p53 and its negative regulator murine double minute 2 homolog (MDM2) have been shown to be closely associated with tumorigenesis in a variety of human cancers. In the present study, single nucleotide polymorphism (SNP) at p53 codon 72 and MDM2 promoter 309 was examined for germline DNA samples from 102 endometrial cancer cases and 95 controls using polymerase chain reaction-based fragment analysis. There were no significant differences in the genotype and allele prevalence between control subjects and endometrial cancer patients for p53 codon 72. The GG genotype frequency of MDM2-SNP309 was statistically higher in endometrial cancer patients than that in normal healthy women when compared with the TG genotype ( P = 0.0088). However, no statistically significant differences were found between the TT and TG or GG genotype frequencies and allele prevalence. Interestingly, the combination of the homozygous Arg/Arg genotype of p53 codon 72 and homozygous GG genotype of MDM2 SNP309 polymorphisms was significantly associated with the risk of endometrial cancer (odds ratio = 3.28, 95% confidence interval = 1.13 to 9.53, P = 0.0212). The homozygous variants of wild p53 codon 72 and mutant MDM2 promoter 309 may cooperatively increase the risk of endometrial cancer in a Japanese population.
Keywords:endometrial cancer  MDM2 SNP309  p53 codon 72  polymorphism
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号