Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX |
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| Authors: | Xie Anyong Scully Ralph |
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| Affiliation: | Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. |
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| Abstract: | In a step toward clarifying how acute viral infections provoke the host DNA damage response, Tarakanova et al. (2007) characterized a gamma-herpesvirus protein, which phosphorylates histone H2AX during infection, suggesting that the virus actively initiates and benefits from the host DNA damage response. |
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